Further, upon treatment with an estrogen receptor 2 (Esr2) antagonist, PHTPP, we observed the opposite phenotypes. Interestingly, exposure to the xenoestrogens ethinylestradiol and genistein yielded the same changes in distal segments. These changes were noted early in development but were not due to changes in cell dynamics. Here, we report that exogenous estrogen treatments affect distal tubule composition, namely, causing an increase in the distal early segment and a decrease in the neighboring distal late. E2 has been extensively studied in the context of gonad development, but roles for E2 in nephron development were unknown. 17β-estradiol (E2), which is the dominant form of estrogen in vertebrates, was a particularly interesting hit from this screen. In an effort to identify elusive regulators of nephron segmentation, our lab conducted a high-throughput drug screen using a bioactive chemical library and developing zebrafish, which are a conserved vertebrate model and particularly conducive to large-scale screening approaches. 718 pp.Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. Analysis of growth zones and microstructure in otoliths of two macrourids from the North Pacific abyss. Daily otolith increments and recruitment in two coral reef wrasses, Thalassoma bifasciatum and Halichoeres bivittatus. Effects of salinity, formalin concentration and buffer on quality of preservation of southern flounder ( Paralichthys lethostigma) larvae. Aspects of the early life history of the Japanese eel Anguilla japonica determined from otolith microstructure. Dissertation, College of William and Mary, Williamsburg. Early life history of weakfish Cynoscion regalis (Bloch and Schneider). Ontogenic development of surface ornamentation in the scales of Hemichromis bimaculatus (Cichlidae). Validation of daily increment deposition in the otoliths of spot ( Leiostomus xanthurus). Reproduction, movements, and population dynamics of sand seatrout, Cynoscion arenarius. Hall (eds.) The Age and Growth of Fish, Iowa State University Press, Ames. Reliability of age and growth-rate estimates derived from otolith analysis. Fish otoliths: daily growth layers and periodical patterns. Geographical differences in early growth of the walleye pollock Theragra chalcogramma, estimated by back-calculation of otolith growth increments. Effects of feeding regimes and diel temperature cycles on otolith increment formation in juvenile chinook salmon, Oncorhynchus tshawytscha. Age and growth of larval Atlantic herring ( Clupea harengus L.) in the Gulf of Maine - Georges Bank region based on otolith growth increments. A technique and the effectiveness of various acrylic colors for subcutaneous marking of fish. Distribution, feeding, and growth of larval walleye pollock, Theragra chalcogramma, from Shelikof Strait, Gulf of Alaska. Age and growth of co-occurring larvae of two flounder species, Rhombosolea tapirina and Ammotretis rostratus. Timing and relative intensity of size-selective mortality of juvenile chum salmon ( Oncorhynchus keta) during early sea life. Statistical interrelation of length, growth, and scale circulus spacing: appraisal of a growth rate estimator for fish. Spawning, age determination, longevity, and mortality of the silver seatrout, Cynoscion nothus, in the Gulf of Mexico. Otolith ultrastructure of smooth oreo, Pseudocyttus maculatus, and black oreo, Allocyttus sp., species. Life history, feeding habits, and functional morphology of juvenile sciaenid fishes in the York River Estuary, Virginia. Otolith microstructure of larval herring ( Clupea harengus): image or reality? Can. Daily growth increments in otoliths of starry flounder ( Platichthys stellatus) and the influence of some environmental variables in their production. Circuli spacing and annulus formation: is there more than meets the eye? The case for sockeye salmon, Oncorhynchus nerka.
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